1

Histone dynamics and single cell technologies:

1. Investigate population and single cell histone dynamics and how dosage imbalances impinge on such dynamics
2. Develop techniques to measure hydroxymethylome and transcriptome from the same cell
2

Chromatin state transitions in early development

1. Define the key chromatin-related components that shape early embryonic decisions
2. Understand the pathways that drive the embryonic chromatin formation
3. Study symmetric and asymmetric divisions using single cell transcriptomics
3

Mapping chromatin structure and function during differentiation

1. Analyse the epigenetic states through differentiation
2. Identify key players that regulate epigenetic changes during ESC differentiation
3. Understand the higher order structure of the genome in general and of chromosome X in particular.
4

Chromatin regulation in selected disease models of iPSCs

Elucidate chromatin related pathways in Williams-Beuren Syndrome, 7q11.23 microduplication syndrome,         Weaver Syndrome and Kabuki Syndrome
1

Histone dynamics and single cell technologies:

1. Investigate population and single cell histone dynamics and how dosage imbalances impinge on such dynamics
2. Develop techniques to measure hydroxymethylome and transcriptome from the same cell
2

Chromatin state transitions in early development

1. Define the key chromatin-related components that shape early embryonic decisions
2. Understand the pathways that drive the embryonic chromatin formation
3. Study symmetric and asymmetric divisions using single cell transcriptomics
3

Mapping chromatin structure and function during differentiation

1. Analyse the epigenetic states through differentiation
2. Identify key players that regulate epigenetic changes during ESC differentiation
3. Understand the higher order structure of the genome in general and of chromosome X in particular.
4

Chromatin regulation in selected disease models of iPSCs

Elucidate chromatin related pathways in Williams-Beuren Syndrome, 7q11.23 microduplication syndrome, Weaver Syndrome and Kabuki Syndrome